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An antimicrobial zinc based molecule for cross linking poly-acrylic acid


Reference:

James, C., Pugh, T., Johnson, A. L. and Jenkins, A. T. A., 2011. An antimicrobial zinc based molecule for cross linking poly-acrylic acid. European Polymer Journal, 47 (6), pp. 1338-1345.

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Official URL:

http://dx.doi.org/10.1016/j.eurpolymj.2011.02.010

Abstract

A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES) 2) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn2+), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)2) and copolymers of Zn(Bipy-(MMOES)2) with acrylic acid (AA). The AA - Zn(Bipy-(MMOES)2) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES) 2) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).

Details

Item Type Articles
CreatorsJames, C., Pugh, T., Johnson, A. L. and Jenkins, A. T. A.
DOI10.1016/j.eurpolymj.2011.02.010
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code24286

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