An antimicrobial zinc based molecule for cross linking poly-acrylic acid

Reference:

James, C., Pugh, T., Johnson, A. L. and Jenkins, A. T. A., 2011. An antimicrobial zinc based molecule for cross linking poly-acrylic acid. European Polymer Journal, 47 (6), pp. 1338-1345.

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Official URL:

http://dx.doi.org/10.1016/j.eurpolymj.2011.02.010

Abstract

A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES) 2) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn2+), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)2) and copolymers of Zn(Bipy-(MMOES)2) with acrylic acid (AA). The AA - Zn(Bipy-(MMOES)2) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES) 2) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).

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