Boronic acid based modular fluorescent sensors for glucose


Phillips, M. D. and James, T. D., 2004. Boronic acid based modular fluorescent sensors for glucose. Journal of Fluorescence, 14 (5), pp. 549-559.

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Modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid groups, one or two fluorophores: pyrene(a), phenanthrene(b), anthracene(c), 1-naphthalene( d), 2-naphthalene(e) and alkylene linkers, from trimethylene(3) to octamethylene(8), have been evaluated. Systems with a single pyrene fluorophore 3(4a), 3(5a) and 3(6a) bind the strongest with D-glucose (3(6a) also binds well with D-melibiose). Whilst 3(7a) and 3(8a) bind the strongest with D-galactose. Changing the fluorophore, also, influences the binding, 3(6a), 3(6b) and 3(6c) are D-glucose selective, whilst 3(6d) and 3(6e) are D-galactose selective. Systems with two fluorophores 3(6a-a) and 3(6a-b) show an overall decrease in binding efficiency. Energy transfer in 3(6a-b) results in enhanced sensitivity and selectivity towards D-glucose.


Item Type Articles
CreatorsPhillips, M. D.and James, T. D.
DepartmentsFaculty of Science > Chemistry
ID Code24632


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