Research

Artificial receptors as chemosensors for carbohydrates


Reference:

James, T. D. and Shinkai, S., 2001. Artificial receptors as chemosensors for carbohydrates. Topics in Current Chemistry, 218 (2002), pp. 159-200.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below.

Official URL:

http://dx.doi.org/10.1007/3-540-45010-6_6

Abstract

As the chemistry of saccharides and related molecular species plays a significant role in the metabolic pathways of living organisms, detecting the presence and concentration of biologically important sugars in aqueous solution is necessary in a variety of medicinal and industrial contexts. The recognition Of D-glucose is of particular interest, for example in the monitoring of diabetics. Recent research provides clear evidence that tight control of blood sugar levels in diabetics sharply reduces the risk of long term complications, which include blindness, kidney failure, heart attacks and even gangrene and amputation of the limbs. Current enzymatic detection methods of sugars offer specificity for only a few saccharides; additionally, enzyme based sensors are unstable in harsh conditions. Phenylboronic acid has been known for 120 years. However, it took until 1959 for the first quantitative evaluation of saccharide boronic acid interactions. Boronic acids react with 1,2 or 1,3 diols of saccharides to form five- or six-membered cyclic esters in non-aqueous or basic aqueous media. The stable boronic acid-based saccharide receptors offer the possibility of creating saccharide sensors 'chemosensors' which are selective and sensitive for any chosen sacchairde.

Details

Item Type Articles
CreatorsJames, T. D.and Shinkai, S.
DOI10.1007/3-540-45010-6_6
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code24641

Export

Actions (login required)

View Item