Judd, K. E. and Caggiano, L., 2011. Bi(OTf)3-catalysed prenylation of electron-rich aryl ethers and phenols with isoprene: a direct route to prenylated derivatives. Organic and Biomolecular Chemistry, 9 (14), pp. 5201-5210.
Electron-rich aryl ethers and phenols react with isoprene (2-methylbuta-1,3-diene) in the presence of catalytic Bi(OTf)(3) at 40 degrees C to afford the corresponding prenylated or 2,2-dimethylchroman products, respectively, in moderate to good yields. This transformation offers a convenient and expedient entry to prenylated derivatives of electron-rich aromatics that often display enhanced biological activities. The methodology has been employed in the efficient synthesis of a biologically active natural product and related compounds.
|Item Type ||Articles|
|Creators||Judd, K. E.and Caggiano, L.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
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