Research

Bath Breakfast Project (BBP) - Examining the Role of Extended Daily Fasting in Human Energy Balance and Associated Health Outcomes: study protocol for a randomised controlled trial [ISRCTN31521726].


Reference:

Betts, J. A., Thompson, D., Richardson, J. D., Chowdhury, E. A., Jeans, M., Holman, G. D. and Tsintzas, K., 2011. Bath Breakfast Project (BBP) - Examining the Role of Extended Daily Fasting in Human Energy Balance and Associated Health Outcomes: study protocol for a randomised controlled trial [ISRCTN31521726]. Trials, 12, 172.

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    Official URL:

    http://dx.doi.org/10.1186/1745-6215-12-172

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    Abstract

    Background: Current guidance regarding the role of daily breakfast in human health is largely grounded in cross-sectional observations. However, the causal nature of these relationships has not been fully explored and what limited information is emerging from controlled laboratorybased experiments appears inconsistent with much existing data. Further progress in our understanding therefore requires a direct examination of how daily breakfast impacts human health under free-living conditions. Methods/Design: The Bath Breakfast Project (BBP) is a randomised controlled trial comparing the effects of daily breakfast consumption relative to extended fasting on energy balance and human health. Approximately 70 men and women will undergo extensive laboratory-based assessments of their acute metabolic responses under fasted and post-prandial conditions, to include: resting metabolic rate, substrate oxidation, dietaryinduced thermogenesis and systemic concentrations of key metabolites/hormones. Physiological and psychological indices of appetite will also be monitored both over the first few hours of the day (i.e. whether fed or fasted) and also following a standardised test lunch used to assess voluntary energy intake under controlled conditions. Baseline measurements of participants’ anthropometric characteristics (e.g. DEXA) will be recorded prior to intervention, along with an oral glucose tolerance test and acquisition of adipose tissue samples to determine expression of key genes and estimates of tissue-specific insulin action. Participants will then be randomly assigned either to a group prescribed an energy intake of ≥3000 kJ before 1100 each day or a group to extend their overnight fast by abstaining from ingestion of energy-providing nutrients until 1200 each day, with all laboratory-based measurements followed-up 6 weeks later. Freeliving assessments of energy intake (via direct weighed food diaries) and energy expenditure (via combined heart-rate/accelerometry) will be made during the first and last week of intervention, with continuous glucose monitors worn both to document chronic glycaemic responses to the intervention and to verify compliance. Trial registration: Current Controlled Trials ISRCTN31521726.

    Details

    Item Type Articles
    CreatorsBetts, J. A., Thompson, D., Richardson, J. D., Chowdhury, E. A., Jeans, M., Holman, G. D. and Tsintzas, K.
    DOI10.1186/1745-6215-12-172
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    URLURL Type
    http://dx.doi.org/10.1186/1745-6215-12-172Free Full-text
    DepartmentsFaculty of Humanities & Social Sciences > Health
    Faculty of Science > Biology & Biochemistry
    Publisher StatementBetts_Trials_2011_12_172.pdf: © 2011 Betts et al. ; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    RefereedYes
    StatusPublished
    ID Code24894

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