Research

Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters


Reference:

Peed, J., Dominguez, I. P., Davies, I. R., Cheeseman, M., Taylor, J. E., Kociok-Kohn, G. and Bull, S. D., 2011. Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters. Organic Letters, 13 (14), pp. 3592-3595.

Related documents:

[img]
Preview
PDF (Bull_OrgLett_2011_13_14_3592.pdf) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (9MB) | Preview

    Official URL:

    http://dx.doi.org/10.1021/ol2012023

    Abstract

    A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.

    Details

    Item Type Articles
    CreatorsPeed, J., Dominguez, I. P., Davies, I. R., Cheeseman, M., Taylor, J. E., Kociok-Kohn, G. and Bull, S. D.
    DOI10.1021/ol2012023
    DepartmentsFaculty of Science > Chemistry
    Publisher StatementBull_OrgLett_2011_13_14_3592.pdf: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol2012023
    RefereedYes
    StatusPublished
    ID Code24976

    Export

    Actions (login required)

    View Item

    Document Downloads

    More statistics for this item...