Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters
Reference:
Peed, J., Dominguez, I. P., Davies, I. R., Cheeseman, M., Taylor, J. E., Kociok-Kohn, G. and Bull, S. D., 2011. Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters. Organic Letters, 13 (14), pp. 3592-3595.
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Official URL:
http://dx.doi.org/10.1021/ol2012023
Abstract
A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.
Details
| Item Type | Articles |
| Creators | Peed, J., Dominguez, I. P., Davies, I. R., Cheeseman, M., Taylor, J. E., Kociok-Kohn, G. and Bull, S. D. |
| DOI | 10.1021/ol2012023 |
| Departments | Faculty of Science > Chemistry |
| Publisher Statement | Bull_OrgLett_2011_13_14_3592.pdf: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol2012023 |
| Refereed | Yes |
| Status | Published |
| ID Code | 24976 |
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