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Allosteric interaction of metal ions with saccharides in a crowned diboronic acid


Reference:

Deng, G., James, T. D. and Shinkai, S., 1994. Allosteric interaction of metal ions with saccharides in a crowned diboronic acid. Journal of the American Chemical Society, 116 (11), pp. 4567-4572.

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Official URL:

http://dx.doi.org/10.1021/ja00090a004

Abstract

A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

Details

Item Type Articles
CreatorsDeng, G., James, T. D. and Shinkai, S.
DOI10.1021/ja00090a004
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code25065

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