Development of metal complexes as potential antimicrobials


Bolhuis, A. and Richards, A. D., 2011. Development of metal complexes as potential antimicrobials. In: Aldrich-Wright, J., ed. Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules. New York: Springer, pp. 373-388.

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In 1969, the Surgeon General of the USA said that it was time “to close the book on infectious diseases” on the basis of the prolific success of antibiotics in the previous quarter century that had been widely prescribed [1]. This optimism, whilst seemingly justified at the time, was seriously misjudged, as the intervening 40 years have clearly demonstrated. This is because of the previously disregarded ability of bacteria to genetically mutate to an extent where future generations of bacteria proved immune to the effects of specific antibiotics – hence the need for novel approaches to combating microbial infections is as great as ever.


Item Type Book Sections
CreatorsBolhuis, A.and Richards, A. D.
EditorsAldrich-Wright, J.
DepartmentsFaculty of Science > Pharmacy & Pharmacology
ID Code25069


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