Activities and modes of action of artificial ion channel mimics


Fyles, T. M., James, T. D. and Kaye, K. C., 1993. Activities and modes of action of artificial ion channel mimics. Journal of the American Chemical Society, 115 (26), pp. 12315-12321.

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The transport of alkali metal cations across vesicle bilayer membranes mediated by a series of 21 synthetic transporters was investigated by a pH-stat technique. The relative activities of the most active synthetic transporters were comparable to valinomycin but a factor 2-20-fold less active than gramicidin. Transport activity is controlled by structural variables; the most active materials have hydrophilic head groups, a balance of hydrophilic and lipophilic groups in the wall units, and overall length compatible with the bilayer thickness. Cation selectivity among the alkali metals, inhibition of transport by a competing cation, apparent kinetic order in transporter, and the ability of transporters to move between vesicles were determined. Significant inhibition of cation transport by competing cations, non-Eisenman selectivity patterns, and zero-order transport kinetics are proposed as criteria to recognize channel-like transporters. By these criteria, six transporters apparently act as channels, and a further four apparently act as carriers of cations. Structural variables control the mode of action of the synthetic transporters, with channel-like behavior most closely associated with columnar structures.


Item Type Articles
CreatorsFyles, T. M., James, T. D. and Kaye, K. C.
DepartmentsFaculty of Science > Chemistry
ID Code25073


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