The effect of complement C5a on mitochondrial functions of PC12 cells


Martinus, R. D. and Cook, C. J., 2011. The effect of complement C5a on mitochondrial functions of PC12 cells. Neuroreport, 22 (12), pp. 581-585.

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C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during apoptosis, we investigated mitochondria as a potential target for C5a. Using PC12 cells, we demonstrated that exposure to C5a led to inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities. Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 was also observed, confirming a marked effect of C5a on mitochondrial functions. These observations are the first documented intracellular effects noted for the complement molecule C5a in in-vitro cultured cells.


Item Type Articles
CreatorsMartinus, R. D.and Cook, C. J.
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Uncontrolled Keywordscomplement,mitochondria,chaperonin 60,c5a,neuronal
DepartmentsFaculty of Humanities & Social Sciences > Health
ID Code25086


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