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Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes


Reference:

Ward, S. G., Westwick, J. and Harris, S., 2011. Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes. Immunology Letters, 138 (1), pp. 15-18.

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Official URL:

http://dx.doi.org/10.1016/j.imlet.2011.02.007

Abstract

Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.

Details

Item Type Articles
CreatorsWard, S. G., Westwick, J. and Harris, S.
DOI10.1016/j.imlet.2011.02.007
Uncontrolled Keywordsmigration, inhibitors, t lymphocytes, pi3k
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code25095

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