Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes
Ward, S. G., Westwick, J. and Harris, S., 2011. Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes. Immunology Letters, 138 (1), pp. 15-18.
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Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.
|Creators||Ward, S. G., Westwick, J. and Harris, S.|
|Uncontrolled Keywords||migration, inhibitors, t lymphocytes, pi3k|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
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