Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis

Reference:

Gliddon, A. E., Dore, C. J., Dunphy, J., Betteridge, Z., McHugh, N. J. and Maddison, P. J., 2011. Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis. Journal of Rheumatology, 38 (4), pp. 702-705.

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Official URL:

http://dx.doi.org/10.3899/jrheum.100754

Abstract

Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (IcSSc). Methods. Sera from 180 patients with IcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at IcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with IcSSc belong to distinctive serologic subsets, potentially with prognostic significance.

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