BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000
Yee, C. S., Isenberg, D. A., Prabu, A., Sokoll, K., Teh, L. S., Rahman, A., Bruce, I. N., Griffiths, B., Akil, M., McHugh, N. J., D'Cruz, D., Khamashta, M. A., Maddison, P., Zoma, A. and Gordon, C., 2008. BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000. Annals of the Rheumatic Diseases, 67 (6), pp. 873-876.
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Objective: To assess the reliability of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 index in routine practice and its ability to capture disease activity as compared with the British Isles Lupus Assessment Group (BILAG)-2004 index. Methods: Patients with systemic lupus erythematosus from 11 centres were assessed separately by two raters in routine practice. Disease activity was assessed using the BILAG-2004 and SLEDAI-2000 indices. The level of agreement for items was used to assess the reliability of SLEDAI-2000. The ability to detect disease activity was assessed by determining the number of patients with a high activity on BILAG-2004 (overall score A or B) but low SLEDAI-2000 score (= 6). Treatment of these patients was analysed, and the increase in treatment was used as the gold standard for active disease. Results: 93 patients (90.3% women, 69.9% Caucasian) were studied: mean age was 43.8 years, mean disease duration 10 years. There were 43 patients (46.2%) with a difference in SLEDAI-2000 score between the two raters and this difference was >= 4 in 19 patients (20.4%). Agreement for each of the items in SLEDAI-2000 was between 81.7 and 100%. 35 patients (37.6%) had high activity on BILAG-2004 but a low SLEDAI-2000 score, of which 48.6% had treatment increased. There were only five patients (5.4%) with low activity on BILAG-2004 but a high SLEDAI-2000 score. Conclusions: SLEDAI-2000 is a reliable index to assess systemic lupus erythematosus disease activity but it is less able than the BILAG-2004 index to detect active disease requiring increased treatment.
|Creators||Yee, C. S., Isenberg, D. A., Prabu, A., Sokoll, K., Teh, L. S., Rahman, A., Bruce, I. N., Griffiths, B., Akil, M., McHugh, N. J., D'Cruz, D., Khamashta, M. A., Maddison, P., Zoma, A. and Gordon, C.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
Faculty of Humanities & Social Sciences > Health
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