Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis
Gunawardena, H., Wedderburn, L. R., North, J., Betteridge, Z., Dunphy, J., Chinoy, H., Davidson, J. E., Cooper, R. G., McHugh, N. J. and Juvenile Dermatomy Res Grp, U. K., 2008. Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology, 47 (3), pp. 324-328.
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Objective. Myositis-specific autoantibodies (MSAs) may define homogeneous clinical subsets of adult patients with dermatomyositis (DM). Recently, there have been descriptions of novel autoantibodies in DM. This study was conducted to establish the clinical significance of antip-155/140 autoantibodies in juvenile DM (JDM). Methods. The first 116 children recruited to the JDM National Registry and Repository (UK and Ireland) were studied. Comprehensive clinical features were recorded and sera screened for anti-p155/140 autoantibodies using radio-immunoprecipitation. Sera from adults with DM (n=20), PM (n=25), SSc (n=150), SLE (n=40) and healthy subjects (n=50) were used for comparison. Immunodepletion experiments were used to establish whether the p155/140 kDa targets recognized by JDM sera were the same as adult DM sera. Results. Twenty-seven out of 116 (23%) JDM cases were positive for anti-p155/140 in comparison with 6/20 (30%) adults with DM. Immunodepletion confirmed that the 155/140kDa proteins recognized by JDM and adult DM sera were the same targets. All other adult control sera were negative for anti-p155/140 autoantibodies. There was a higher frequency of males in the anti-p155/140-positive JDM group (P=0.02). JDM patients with anti-p155/140 autoantibodies had significantly more cutaneous involvement including Gottron's papules (P=0.003), ulceration (P=0.005) and oedema (P=0.013). The distribution of skin lesions was more extensive particularly periorbitally (P=0.014) and over the small (P<0.001) and large joints (P=0.003). Conclusion. Anti-p155/140 autoantibodies are clinically significant in JDM and may define a clinical subset in terms of disease severity and outcome. The same autoantigen target is detected in adult DM patients.
|Creators||Gunawardena, H., Wedderburn, L. R., North, J., Betteridge, Z., Dunphy, J., Chinoy, H., Davidson, J. E., Cooper, R. G., McHugh, N. J. and Juvenile Dermatomy Res Grp, U. K.|
|Departments||Faculty of Humanities & Social Sciences > Health|
Faculty of Science > Pharmacy & Pharmacology
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