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Steroid sulfatase : a pivotal player in estrogen synthesis and metabolism


Reference:

Purohit, A., Woo, L. W. L. and Potter, B. V. L., 2011. Steroid sulfatase : a pivotal player in estrogen synthesis and metabolism. Molecular and Cellular Endocrinology, 340 (2), pp. 154-160.

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    Official URL:

    http://dx.doi.org/10.1016/j.mce.2011.06.012

    Abstract

    Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to steroids with estrogenic properties (i.e. estradiol and androstenediol) that can stimulate the growth of tumors in hormone-responsive tissues of the breast, endometrium and prostate. Hence, the action of steroid sulfatase is implicated in physiological processes and pathological conditions. It has been five years since our group last reviewed the important role of this enzyme in steroid synthesis and the progress made in the development of potent inhibitors of this important enzyme target. This timely review therefore concentrates on recent advances in steroid sulfatase research, and summarises the findings of clinical trials with Irosustat (BN83495), the only steroid sulfatase inhibitor that is being trialed in postmenopausal women with breast or endometrial cancer.

    Details

    Item Type Articles
    CreatorsPurohit, A., Woo, L. W. L. and Potter, B. V. L.
    DOI10.1016/j.mce.2011.06.012
    Uncontrolled Keywordsbreast cancer, irosustat, steroid sulfatase inhibitors, dheas, androstenediol, bn83495, estrogens
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    RefereedYes
    StatusPublished
    ID Code25704

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