Research

Swatting flies: modelling wound healing and inflammation in Drosophila


Reference:

Razzell, W., Wood, W. and Martin, P., 2011. Swatting flies: modelling wound healing and inflammation in Drosophila. Disease Models & Mechanisms, 4 (5), pp. 569-574.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1242/dmm.006825

Related URLs:

Abstract

Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic intervention, we need a better understanding of the fundamental mechanisms driving tissue repair; this will require complementary wound-healing studies in several model organisms. Drosophila has been used to model genetic aspects of numerous human pathologies, and is being used increasingly to gain insight into the molecular and genetic aspects of tissue repair and inflammation, which have classically been modelled in mice or cultured cells. This review discusses the advantages and disadvantages of Drosophila as a wound-healing model, as well as some exciting new research opportunities that will be enabled by its use.

Details

Item Type Articles
CreatorsRazzell, W., Wood, W. and Martin, P.
DOI10.1242/dmm.006825
Related URLs
URLURL Type
http://dx.doi.org/10.1242/dmm.006825Free Full-text
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code25945

Export

Actions (login required)

View Item