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Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives


Reference:

Ciupa, A., Griffiths, N. J., Light, S. K., Wood, P. J. and Caggiano, L., 2011. Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives. MedChemComm, 2 (10), pp. 1011-1015.

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      Official URL:

      http://dx.doi.org/10.1039/C1MD00155H

      Abstract

      Inspired by biologically active natural products, a hybrid analogue that combines the N-Me urocanic side chain of the sarcodictyin family of compounds with the chalcone motif has been proposed, synthesised and examined for antiproliferative activity in three cancer cell lines and one normal primary cell line. The analogues are all synthesised in one or two steps from commercially available materials and, of the compounds examined, the proposed hybrid analogue displays the most active and selective inhibition of cell proliferation in human colon cancer cell line HT29 (IC50 2.9 μM) and highly metastatic human breast carcinoma MDA-MB-231 (IC50 4.8 μM).

      Details

      Item Type Articles
      CreatorsCiupa, A., Griffiths, N. J., Light, S. K., Wood, P. J. and Caggiano, L.
      DOI10.1039/C1MD00155H
      DepartmentsFaculty of Science > Pharmacy & Pharmacology
      RefereedYes
      StatusPublished
      ID Code26740

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