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Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes


Reference:

Pascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., Sim, R. B., Churchill, G. C., Aigbirhio, F. I. and Warren, J. E., 2008. Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. Dalton Transactions, 2008 (16), pp. 2107-2110.

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Official URL:

http://dx.doi.org/10.1039/b802806k

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

Details

Item Type Articles
CreatorsPascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., Sim, R. B., Churchill, G. C., Aigbirhio, F. I. and Warren, J. E.
DOI10.1039/b802806k
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code27163

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