Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes
Reference:
Pascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., Sim, R. B., Churchill, G. C., Aigbirhio, F. I. and Warren, J. E., 2008. Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. Dalton Transactions
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Official URL:
http://dx.doi.org/10.1039/b802806k
Abstract
We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Details
| Item Type | Articles |
| Creators | Pascu, S. I., Waghorn, P. A., Conry, T. D., Lin, B., Betts, H. M., Dilworth, J. R., Sim, R. B., Churchill, G. C., Aigbirhio, F. I. and Warren, J. E. |
| DOI | 10.1039/b802806k |
| Departments | Faculty of Science > Chemistry |
| Refereed | Yes |
| Status | Published |
| ID Code | 27163 |
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