Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts


Chen, L., Tovar-Corona, J. M. and Urrutia, A. O., 2011. Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts. Human Molecular Genetics, 20 (22), pp. 4422-4429.

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    Recent genome-wide analyses have detected numerous cancer-specific alternative splicing (AS) events. Whether transcripts containing cancer-specific AS events are likely to be translated into functional proteins or simply reflect noisy splicing, thereby determining their clinical relevance, is not known. Here we show that consistent with a noisy-splicing model, cancer-specific AS events generally tend to be rare, containing more premature stop codons and have less identifiable functional domains in both the human and mouse. Interestingly, common cancer-derived AS transcripts from tumour suppressor and oncogenes show marked changes in premature stop-codon frequency; with tumour suppressor genes exhibiting increased levels of premature stop codons whereas oncogenes have the opposite pattern. We conclude that tumours tend to have faithful oncogene splicing and a higher incidence of premature stop codons among tumour suppressor and cancer-specific splice variants showing the importance of considering splicing noise when analysing cancer-specific splicing changes.


    Item Type Articles
    CreatorsChen, L., Tovar-Corona, J. M. and Urrutia, A. O.
    DepartmentsFaculty of Science > Biology & Biochemistry
    Publisher Statementurrutia_2011.pdf: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    ID Code27256


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