Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. and Roberts, M. S., 2011. Mathematical models of skin permeability: An overview. International Journal of Pharmaceutics, 418 (1), pp. 115-129.
Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects.
|Item Type ||Articles|
|Creators||Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. and Roberts, M. S.|
|Uncontrolled Keywords||model, exposure assessment, mathematical, transdermal, theory, permeability, stratum corneum|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Publisher Statement||Guy_IJP_2011_418_1_115.pdf: NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, Vol 418, Issue 1, 2011, DOI 10.1016/j.ijpharm.2011.02.023|
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