The MDCK variety pack: choosing the right strain


Dukes, J. D., Whitley, P. and Chalmers, A. D., 2011. The MDCK variety pack: choosing the right strain. BMC Cell Biology, 12, 43.

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    The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells. However, there are many different strains of MDCK cells available, including the parental line, MDCK I, MDCK II, MDCK. 1, MDCK. 2, superdome and supertube, making it difficult for new researchers to decide which strain to use. Furthermore, there is often inadequate reporting of strain types and where cells were obtained from in the literature. This review aims to provide new researchers with a guide to the different MDCK strains and a directory of where they can be obtained. We also hope to encourage experienced researchers to report the stain and origin of their MDCK cells.


    Item Type Articles
    CreatorsDukes, J. D., Whitley, P. and Chalmers, A. D.
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    URLURL Type Full-text
    DepartmentsFaculty of Science > Biology & Biochemistry
    Research CentresCentre for Regenerative Medicine
    Publisher Statementdukes_MDCK_review_2011_.pdf: © 2011 Dukes et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    ID Code27569


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