Mechanical characteristics of antibiotic-laden bone cement
Armstrong, M. S., Spencer, R. F., Cunningham, J. L., Gheduzzi, S., Miles, A. W. and Learmonth, I. D., 2002. Mechanical characteristics of antibiotic-laden bone cement. Acta Orthopaedica Scandinavica, 73 (6), pp. 688-690.
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We studied the mechanical characteristics of cement-antibiotic combinations in vitro. Palacos R was tested without antibiotics, with gentamicin alone and with gentamicin plus vancomycin or flucloxacillin. Palacos LV was studied only with gentamicin added. CMW 1 was studied with gentamicin added, with gentamicin plus vancomycin, and with gentamicin plus flucloxacillin. We performed four-point bending tests on beams of cement to establish bending strength and modulus, and compared the values to ISO standards. Density was also assessed. Palacos R was the strongest of the cements (bending strength 80 MPa). Palacos formulations (apart from Palacos LV) had a higher density and bending modulus than CMW 1. Statistical comparison of various cements with plain Palacos R showed lower density in 4 of the mixtures, and lower bending strength and modulus in 6 of the mixtures. Palacos R/gentamicin plus vancomycin and CMW 1/gentamicin plus vancomycin had bending strength slightly above minimum ISO standards, suggesting that the addition of vancomycin during cement mixing may compromise the outcome in revision surgery for sepsis.
|Creators||Armstrong, M. S., Spencer, R. F., Cunningham, J. L., Gheduzzi, S., Miles, A. W. and Learmonth, I. D.|
|Departments||Faculty of Engineering & Design > Mechanical Engineering|
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