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A polymorphism in the CTGF promoter region associated with systemic sclerosis


Reference:

Fonseca, C., Lindahl, G. E., Ponticos, M., Sestini, P., Renzoni, E. A., Holmes, A. M., Spagnolo, P., Pantelidis, P., Leoni, P., McHugh, N. J., Stock, C. J., Shi-Wen, X., Denton, C. P., Black, C. M., Welsh, K. I., du Bois, R. M. and Abraham, D. J., 2007. A polymorphism in the CTGF promoter region associated with systemic sclerosis. The New England Journal of Medicine, 357 (12), pp. 1210-1220.

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Official URL:

http://dx.doi.org/10.1056/NEJMoa067655

Abstract

The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.

Details

Item Type Articles
CreatorsFonseca, C., Lindahl, G. E., Ponticos, M., Sestini, P., Renzoni, E. A., Holmes, A. M., Spagnolo, P., Pantelidis, P., Leoni, P., McHugh, N. J., Stock, C. J., Shi-Wen, X., Denton, C. P., Black, C. M., Welsh, K. I., du Bois, R. M. and Abraham, D. J.
DOI10.1056/NEJMoa067655
DepartmentsFaculty of Science > Pharmacy & Pharmacology
Faculty of Humanities & Social Sciences > Health
RefereedYes
StatusPublished
ID Code27949

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