Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study.

Reference:

Chinoy, H., Adimulam, S., Marriage, F., New, P., Vincze, M., Zilahi, E., Kapitány, A., Gyetvai, A., Ekholm, L., Novota, P., Remakova, M., Charles, P., McHugh, N. J., Padyukov, L., Alfredsson, L., Vencovsky, J., Lundberg, I. E., Danko, K., Ollier, W. E. and Cooper, R. G., 2012. Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study. Annals of the Rheumatic Diseases, 71 (6), pp. 961-965.

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Official URL:

http://dx.doi.org/10.1136/annrheumdis-2011-200182

Related URLs:

• http://dx.doi.org/10.1136/annrheumdis-2011-200182

Abstract

OBJECTIVES: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM.METHODS: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation.RESULTS: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1-positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

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