Intramolecular ester enolate–imine cyclization reactions for the asymmetric synthesis of polycyclic β-lactams and cyclic β-amino acid derivatives
Evans, C. D., Mahon, M. F., Andrews, P. C., Muir, J. and Bull, S. D., 2011. Intramolecular ester enolate–imine cyclization reactions for the asymmetric synthesis of polycyclic β-lactams and cyclic β-amino acid derivatives. Organic Letters, 13 (23), pp. 6276-6279.
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Enolates of chiral N-(alpha-methyl-p-methoxybenzyl)-omega-imino-esters undergo intramolecular cyclization reactions to afford (syn)-aza-anions of beta-amino esters in high dr that cyclize to afford N-(alpha-methyl-p-methoxybenzyl)-beta-lactams that can be readily deprotected to afford their corresponding cyclic NH-beta-lactams, beta-amino esters, or beta-amino acids.
|Creators||Evans, C. D., Mahon, M. F., Andrews, P. C., Muir, J. and Bull, S. D.|
|Departments||Faculty of Science > Chemistry|
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