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Error prevention and mitigation as forces in the evolution of genes and genomes


Reference:

Warnecke, T. and Hurst, L. D., 2011. Error prevention and mitigation as forces in the evolution of genes and genomes. Nature Reviews Genetics, 12 (12), pp. 875-881.

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    Official URL:

    http://dx.doi.org/10.1038/nrg3092

    Abstract

    Why are short introns rarely a multiple of three nucleotides long? Why do essential genes cluster? Why are genes in operons often lined up in the order in which they are needed in the encoded pathway? In this Opinion article, we argue that these and many other - ostensibly disparate - observations are all pieces of an emerging picture in which multiple aspects of gene anatomy and genome architecture have evolved in response to error-prone gene expression.

    Details

    Item Type Articles
    CreatorsWarnecke, T.and Hurst, L. D.
    DOI10.1038/nrg3092
    DepartmentsFaculty of Science > Biology & Biochemistry
    RefereedYes
    StatusPublished
    ID Code28012

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