Allen, C. L., Chhatwal, A. R. and Williams, J. M. J., 2012. Direct amide formation from unactivated carboxylic acids and amines. Chemical Communications, 48 (5), pp. 666-668.
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The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 degrees C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
|Item Type ||Articles|
|Creators||Allen, C. L., Chhatwal, A. R. and Williams, J. M. J.|
|Departments||Faculty of Science > Chemistry|
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