Advanced microscopy techniques to assess solid-state properties of inhalation medicines


Shur, J. and Price, R., 2012. Advanced microscopy techniques to assess solid-state properties of inhalation medicines. Advanced Drug Delivery Reviews, 64 (4), pp. 369-382.

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    Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. Control and reduction of risk require the introduction of a material science based approach to product development and the use of advanced analytical tools in understanding how the solid-state properties of the input materials influence structure and product functionality. The key issues to be addressed, at a microscopic scale, are understanding how the critical quality attributes of input materials influence surface, interfacial and particulate interactions within OIDPs. This review offers an in-depth discussion on the use of advanced microscopy techniques in characterising of the solid-state properties of particulate materials for OIDPs. The review covers the fundamental principles of the techniques, instrumentation types, data interpretation and specific applications in relation to the product development of OIDPs.


    Item Type Articles
    CreatorsShur, J.and Price, R.
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    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Publisher StatementPrice_ADDR_2012.pdf: NOTICE: this is the author’s version of a work that was accepted for publication in Advanced Drug Delivery Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advanced Drug Delivery Reviews, 2012, vol 64, issue 4, DOI 10.1016/j.addr.2011.11.005
    ID Code28209


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