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Si-free enolate Claisen rearrangements of enamido substrates


Reference:

Harker, W. R. R., Carswell, E. L. and Carbery, D. R., 2012. Si-free enolate Claisen rearrangements of enamido substrates. Organic and Biomolecular Chemistry, 10 (7), pp. 1406-1410.

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    Official URL:

    http://dx.doi.org/10.1039/c2ob06853b

    Abstract

    alpha-Alkyl beta-amino esters are available in high diastereoselectivity through a silicon-free Claisen enolate [3,3]-sigmatropic rearrangement of enamide esters. Optimisation studies have probed the crucial role of the initial enolisation and the nature of the enamide N-centre. The demonstration of chirality transfer and the formation of beta-proline systems, is also presented.

    Details

    Item Type Articles
    CreatorsHarker, W. R. R., Carswell, E. L. and Carbery, D. R.
    DOI10.1039/c2ob06853b
    DepartmentsFaculty of Science > Chemistry
    RefereedYes
    StatusPublished
    ID Code28711

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