Passive and iontophoretic transdermal delivery of phenobarbital: implications in paediatric therapy


Djabri, A., Guy, R. H. and Delgado-Charro, M. B., 2012. Passive and iontophoretic transdermal delivery of phenobarbital: implications in paediatric therapy. International Journal of Pharmaceutics, 435 (1), pp. 76-82.

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    The objective of this investigation was to evaluate phenobarbital transdermal delivery for possible use in paediatric care. In vitro experiments were performed using intact pig skin and barriers from which the stratum corneum had been stripped to different extents to model the less resistant skin of premature babies. Cathodal iontophoretic delivery of phenobarbital was superior to anodal transport and optimised delivery conditions were achieved by reduction of competing co-ion presence in the drug formulation. Phenobarbital transport across intact or partially compromised skin was controlled by iontophoresis which was more efficient than passive diffusion. Across highly compromised skin, however, passive diffusion increased drastically and iontophoretic control was lost. Overall, this study demonstrates the feasibility of phenobarbital transdermal delivery for paediatric patients.


    Item Type Articles
    CreatorsDjabri, A., Guy, R. H. and Delgado-Charro, M. B.
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    URLURL Type
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Research CentresCentre for Mathematical Biology
    Publisher StatementDelgardo-Charro_IJP_2012.pdf: NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, vol 435, issue 1, 2012, DOI 10.1016/j.ijpharm.2012.02.026
    ID Code29019


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