The influence of crystals, particles and powders on the performance of dry powder inhalers
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Dry powder inhalers (DPIs) are an attractive means of delivering drugs to the lung. The fluidization, entrainment and de-aggregation of a DPI formulation is a complex relationship between the patient's inspiratory effort, the air flow field generated within a device and the cohesive properties of the powder bed. The inter-relationship between factors including particle size, particle shape, distribution of interparticulate and mechanical forces govern the performance and efficacy of DPI drug delivery systems. However, quantitative measurements of these properties and their under-lying relationships remain difficult to discern. This presentation will focus on some key developments in understanding the relationships between the governing properties of DPIs and how these properties can be harnessed to develop designer formulation systems for DPIs.
|Item Type||Book Sections|
|Creators||Shur, J.and Price, R.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Additional Information||2011 AIChE Annual Meeting, 11AIChE; Minneapolis, MN; 16-21 October 2011.|
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