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Effects of different doses of physical activity on C-reactive protein among women


Reference:

Stewart, L. K., Earnest, C. P., Blair, S. N. and Church, T. S., 2010. Effects of different doses of physical activity on C-reactive protein among women. Medicine and Science in Sports and Exercise, 42 (4), pp. 701-707.

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Official URL:

http://dx.doi.org/10.1249/MSS.0b013e3181c03a2b

Abstract

Elevated C-reactive protein (CRP) is associated with an increased risk of cardiovascular disease. Physical activity has been inversely associated with CRP. However, the clinical trials examining the effect of exercise training have produced conflicting results. Purpose: The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women. Methods: Sedentary, overweight, or obese postmenopausal women with elevated systolic blood pressure (120-160 mm Hg; n = 464) were randomized into one of four groups: a nonexercise control or one of three aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal[middle dot]kg-1[middle dot]wk-1 (KKW) for 6 months at a training intensity of 50% of peak V[spacing dot above]O2. Results: Complete data for 421 participants were available, and mean (SD) baseline CRP was 5.7 (5.5) mg[middle dot]L-1, with no significant differences across groups. Although V[spacing dot above]O2 increased in a dose-response manner, there were no significant changes in CRP in any of the exercise intervention groups compared with the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP. Conclusions: Despite increasing fitness, 6 months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight. (C)2010The American College of Sports Medicine

Details

Item Type Articles
CreatorsStewart, L. K., Earnest, C. P., Blair, S. N. and Church, T. S.
DOI10.1249/MSS.0b013e3181c03a2b
DepartmentsFaculty of Humanities & Social Sciences > Health
RefereedYes
StatusPublished
ID Code29933

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