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Exercise dose-response of the V(E)/VCO(2) slope in postmenopausal women in the DREW study


Reference:

Anaya, S. A., Church, T. S., Blair, S. N., Myers, J. N. and Earnest, C. P., 2009. Exercise dose-response of the V(E)/VCO(2) slope in postmenopausal women in the DREW study. Medicine and Science in Sports and Exercise, 41 (5), pp. 971-976.

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http://dx.doi.org/10.1249/MSS.0b013e3181930009

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Abstract

PURPOSE: Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V(E)/VCO(2) slope, which is predictive of mortality in patients with CHF. Although the V(E)/VCO(2) slope is well established in CHF patients, little is known regarding interventions for "at-risk" populations. METHODS: We examined the V(E)/VCO(2) slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal x kg(-1) x wk(-1) (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline VO(2max). We examined trends in exercise treatment dose versus change in mean V(E)/VCO(2) slope using a linear regression model (KKW vs V(E)/VCO(2) slope) and a linear mixed model. RESULTS: Regression analysis showed a significant trend for a reduction in the V(E)/VCO(2) slope from baseline (mean +/- SD: 32.6 +/- 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V(E)/VCO(2) slope for the 8-KKW (-1.14; 95% CI, -1.5 to -0.2) and 12-KKW (-1.67; 95% CI, -2.3 to -0.3) groups. No significant effect was noted for the 4-KKW (-0.4; 95% CI, -1.2 to 0.15) group. CONCLUSION: Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V(E)/VCO(2) slope in postmenopausal women who exhibit risk factors associated with the development of CHF.

Details

Item Type Articles
CreatorsAnaya, S. A., Church, T. S., Blair, S. N., Myers, J. N. and Earnest, C. P.
DOI10.1249/MSS.0b013e3181930009
Related URLs
URLURL Type
http://www.ncbi.nlm.nih.gov/pubmed/19346992Free Full-text
DepartmentsFaculty of Humanities & Social Sciences > Health
RefereedYes
StatusPublished
ID Code29953
Additional InformationAnaya, Stephanie A Church, Timothy S Blair, Steven N Myers, Jonathan N Earnest, Conrad P HL-66262/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Medicine and science in sports and exercise Med Sci Sports Exerc. 2009 May;41(5):971-6. Exercise and Health

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