Research

Total synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist


Reference:

Swarbrick, J. M. and Potter, B. V. L., 2012. Total synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist. Journal of Organic Chemistry, 77 (9), pp. 4191-4197.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1021/jo202319f

Related URLs:

Abstract

Stable cyclic adenosine 5′-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca 2+ release mechanism and structure-activity relationships of this emerging potent second messenger. However, analogues with an intact "northern" ribose have been inaccessible due to the difficulty of generating the sensitive N1-ribosyl link. We report the first total synthesis of the membrane permeant, hydrolytically stable, cADPR receptor agonist 8-Br-N1-cIDPR via regio- and stereoselective N1-ribosylation of protected 8-bromoinosine.

Details

Item Type Articles
CreatorsSwarbrick, J. M.and Potter, B. V. L.
DOI10.1021/jo202319f
Related URLs
URLURL Type
http://dx.doi.org/10.1021/jo202319fFree Full-text
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code30148

Export

Actions (login required)

View Item