Lewis Acid Mediated Reactions of Olefins with Carbonyls


Flower, S., 2002. Lewis Acid Mediated Reactions of Olefins with Carbonyls. Thesis (Doctor of Philosophy (PhD)). University of Bath.

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This thesis is divided into 5 chapters. The first chapter reviews the literature of Carbonyl-ene and Prins reactions. Recent advances in these areas and their application to natural product synthesis and other targeted syntheses are discussed. The second chapter discusses the concept of desymmetrisation using selected examples, including desymmetrising Carbonyl-ene reactions. Chapter Three introduces and discusses the work undertaken in studying the desymmetrising intramolecular carbonyl-ene of a meso-dialdehyde. Chapter Four details the concept of pyruvate-Prins cyclisation giving examples of its potential use. The chapter also gives examples of the use of rigid stereodefined scaffolds and their application. The chapter describes the reactivity of substituted pyruvate esters with cyclic enol ethers, and the elaboration of the cyclised products. The fifth chapter provides experimental details of the procedures reported.


Item Type Thesis (Doctor of Philosophy (PhD))
CreatorsFlower, S.
DepartmentsFaculty of Science > Chemistry
ID Code30493


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