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Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans


Reference:

Williams, R. J., Dickinson, K., Kinsman, O. S., Bramley, T. A., Menzies, G. S. and Adams, D. J., 1990. Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans. Journal of General Microbiology, 136 (11), pp. 2143-2148.

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http://dx.doi.org/10.1099/00221287-136-11-2143

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Abstract

Human luteinizing hormone (hLH) and the GTP analogue guanosine 5'-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.

Details

Item Type Articles
CreatorsWilliams, R. J., Dickinson, K., Kinsman, O. S., Bramley, T. A., Menzies, G. S. and Adams, D. J.
DOI10.1099/00221287-136-11-2143
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URLURL Type
http://dx.doi.org/10.1099/00221287-136-11-2143Free Full-text
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code30584

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