Research

Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty


Reference:

Gill, H. S., Grammatopoulos, G., Adshead, S., Tsialogiannis, E. and Tsiridis, E., 2012. Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty. Trends in Molecular Medicine, 18 (3), pp. 145-155.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1016/j.molmed.2011.12.002

Related URLs:

Abstract

Theoretical, desirable features of second-generation metal-on-metal (MoM) hip prostheses have led to their widespread use. However, the bearing surfaces, consisting of complex cobalt-chromium alloys, are subject to wear and the release of cobalt and chromium (CoCr) nanoparticles. These nanoparticles can reduce cellular viability, induce DNA damage, lead to chromosomal aberrations, and possibly stimulate increased metal hypersensitivity. Clinically, the effects can be both local (soft-tissue reactions) and systemic (arthroprosthetic cobaltism). This review assesses the literature concerning the in vitro and in vivo cytotoxic, genotoxic, and immunotoxic effects of CoCr wear particles, which is increasingly important in view of the large number of MoM arthroplasties performed.

Details

Item Type Articles
CreatorsGill, H. S., Grammatopoulos, G., Adshead, S., Tsialogiannis, E. and Tsiridis, E.
DOI10.1016/j.molmed.2011.12.002
Related URLs
URLURL Type
http://www.ncbi.nlm.nih.gov/pubmed/22245020PubMedCentral
DepartmentsFaculty of Engineering & Design > Mechanical Engineering
Research CentresCentre for Orthopaedic Biomechanics
RefereedYes
StatusPublished
ID Code30667

Export

Actions (login required)

View Item