Research

Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy


Reference:

Brown, C. P., Houle, M. A., Chen, M., Price, A. J., Legare, F. and Gill, H. S., 2012. Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. Journal of the Mechanical Behavior of Biomedical Materials, 5 (1), pp. 62-70.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1016/j.jmbbm.2011.08.004

Related URLs:

Abstract

With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of fibrils at the surface under normal loading. This bundling appears to be an irreversible step in the degradation process, as the stress concentrations drive the progression of damage, forming larger bundles and cracks that eventually form lesions.

Details

Item Type Articles
CreatorsBrown, C. P., Houle, M. A., Chen, M., Price, A. J., Legare, F. and Gill, H. S.
DOI10.1016/j.jmbbm.2011.08.004
Related URLs
URLURL Type
http://www.ncbi.nlm.nih.gov/pubmed/22100080PubMedCentral
DepartmentsFaculty of Engineering & Design > Mechanical Engineering
Research CentresCentre for Orthopaedic Biomechanics
RefereedYes
StatusPublished
ID Code30669

Export

Actions (login required)

View Item