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Thiol-Functionalising Reagents and Their Uses


Reference:

Watts, A., Kantner, T. and Mackenzie, A., 2011. Thiol-Functionalising Reagents and Their Uses. C07K1/13-EP2373675 (A2), 12 October 2011.

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Abstract

Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

Details

Item Type Patent
CreatorsWatts, A., Kantner, T. and Mackenzie, A.
Uncontrolled Keywords13
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedNo
StatusPublished
ID Code30721

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