Research

Therapeutics


Reference:

Potter, B., Dowden, J., Galione, A., Guse, A. H. and Alexander, F., 2007. Therapeutics. A61K31/452-WO2007132179 (A2), 22 November 2007.

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Abstract

The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.

Details

Item Type Patent
CreatorsPotter, B., Dowden, J., Galione, A., Guse, A. H. and Alexander, F.
Uncontrolled Keywords452
DepartmentsFaculty of Science > Pharmacy & Pharmacology
StatusPublished
ID Code30749

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