Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity
Potter, Barry, 2000. Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity. G01N33/50-WO0037089 (A1), 29 June 2000.
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Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.
|Creators||Potter, B., Guse, A. H., Schulze-Koops, H., Berg, I. and Mayr, G. W.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
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