Pharmaceutical process modelling

Reference:

MacGregor, S. A., Newnes, L. B., Staniforth, J. N., Lamming, R. C., Tobyn, M. J., Li, M., Kay, G. R., Horrill, M. D. and Hajee, D. W., 1996. Pharmaceutical process modelling. In: International Conference on Process Modelling, 1996-01-01, Cottbus.

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Abstract

The use of Computational Fluid Dynamics in the design of a pharmaceutical processor is described. A simple computational model of the process, was developed using a single phase flow. The results of this preliminary study showed good agreement with experimental tests. The model was further developed to consider the effect of solid particles on the process occuring within a single vessel pharmaceutical processor. Having obtained converged solutions the model was used to optimise the design of the processor. The desing optimisation was done on the basis of comparisons with conventional pharmaceutical processing equipment. Optimisation of the process parameters are important as they are known to affect the functionality of the final product

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