The effect of pressure on halothane binding to hydrated DMPC bilayers
Chau, P.-l., Tu, K. M., Liang, K. K., Todorov, I. T., Roser, S. J., Barker, R. and Matubayasi, N., 2012. The effect of pressure on halothane binding to hydrated DMPC bilayers. Molecular Physics, 110 (13), pp. 1461-1467.
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Halothane binding to hydrated dimyristoylphosphatidylcholine (DMPC) bilayer membranes has been examined over a wide range of pressures from 105 to 4 × 108 Pa. We show that the solvation of halothane by the membrane and bulk water are both pressure dependent, with an increased pressure driving halothane into the membrane. Analysis of these results shows that this pressure dependence is not the cause of pressure reversal, the process whereby general anaesthetics lose their efficacy at pressures of about 8 × 106 to about 2.5 × 107 Pa.
|Creators||Chau, P.-l., Tu, K. M., Liang, K. K., Todorov, I. T., Roser, S. J., Barker, R. and Matubayasi, N.|
|Departments||Faculty of Science > Chemistry|
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