Noise-induced metastability in biochemical networks


Biancalani, T., Rogers, T. and McKane, A. J., 2012. Noise-induced metastability in biochemical networks. Physical Review E, 86 (1), 010106(R).

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Intra-cellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different timescales are general features of a broad class of autocatalyic reaction networks, and moreover, that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade.


Item Type Articles
CreatorsBiancalani, T., Rogers, T. and McKane, A. J.
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URLURL Type Full-text
DepartmentsFaculty of Science > Mathematical Sciences
Research Centres
Centre for Mathematical Biology
ID Code32183


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