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The Hippo pathwaya:Key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration


Reference:

Cherrett, C., Furutani-Seiki, M. and Bagby, S., 2012. The Hippo pathwaya:Key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration. Essays in Biochemistry, 53 (1), pp. 111-127.

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    Official URL:

    http://dx.doi.org/10.1042/bse0530111

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    Abstract

    The Hippo pathway is a conserved pathway that interconnects with several other pathways to regulate organ growth, tissue homeostasis and regeneration, and stem cell self-renewal. This pathway is unique in its capacity to orchestrate the multiple processes, from sensing to execution, necessary for organ expansion. Activation of the Hippo pathway core kinase cassette leads to cytoplasmic sequestration of the nuclear effectors YAP and TAZ, consequently disabling their transcriptional coactivation function. Components upstream of the core kinase cassette have not been well understood, especially in vertebrates, but are gradually being elucidated and include cell polarity and cell adhesion proteins. Like many signalling proteins, Hippo pathway proteins are modular and utilise various interaction and catalytic domains to transmit signals and regulate transcription of target genes, often in a context-dependent fashion. In this review we outline the major protein components and focus on the structure and function of some of the key Hippo pathway domains in vertebrates.

    Details

    Item Type Articles
    CreatorsCherrett, C., Furutani-Seiki, M. and Bagby, S.
    DOI10.1042/bse0530111
    Related URLs
    URLURL Type
    http://www.scopus.com/inward/record.url?scp=84871853366&partnerID=8YFLogxKUNSPECIFIED
    http://www.portlandpress.com/pp/books/prod_det.cfm?product=9781855781894Publisher
    DepartmentsFaculty of Science > Biology & Biochemistry
    Research CentresCentre for Regenerative Medicine
    Publisher StatementCherrettFurutaniSeikiBagby_Hippo_final2.pdf: This research was originally published in Essays in Biochemistry. Cherrett, C., Furutani-Seiki, M., & Bagby, S. (2012). The Hippo pathway: key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration. Essays in Biochemistry, 53, 111-127. © the Biochemical Society
    RefereedYes
    StatusPublished
    ID Code34242

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