The insect toxin complex of Yersinia


Waterfield, N., Hares, M., Hinchliffe, S., Wren, B. and Ffrench-Constant, R., 2007. The insect toxin complex of Yersinia. In: Genus Yersinia: From Genomics to Function.Vol. 603. Springer, pp. 247-257. (Advances in Experimental Medicine and Biology)

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Many members of the Yersinia genus encode homologues of insect toxins first observed in bacteria that are insect pathogens such as Photorhabdus, Xenorhabdus and Serratia entomophila. These bacteria secrete high molecular weight insecticidal toxins comprised of multiple protein subunits, termed the Toxin Complexes or Tc's. In Photorhabdus three distinct Tc subunits are required for full oral toxicity in insects, that include the [A], [B] and [C] types, although the exact stochiometry remains unclear. The genomes of Photorhabdus strains encode multiple tc loci, although only two have been shown to exhibit oral and injectable activity against the Hawk Moth, Manduca sexta. The exact role of the remaining homologues is unclear. The availability of bacterial genome sequences has revealed the presence of tc gene homologues in many different species. In this chapter we review the tc gene homologues in Yersinia genus. We discuss what is known about the activity of the Yersinia Tc protein homologues and attempt to relate this to the evolution of the genus and of the tca gene family.


Item Type Book Sections
CreatorsWaterfield, N., Hares, M., Hinchliffe, S., Wren, B. and Ffrench-Constant, R.
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code3473


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