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Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines


Reference:

Ciupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. and Caggiano, L., 2013. Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines. MedChemComm, 4 (6), pp. 956-961.

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http://dx.doi.org/10.1039/C3MD00077J

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Abstract

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.

Details

Item Type Articles
CreatorsCiupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. and Caggiano, L.
DOI10.1039/C3MD00077J
Related URLs
URLURL Type
http://www.scopus.com/inward/record.url?scp=84878798574&partnerID=8YFLogxKUNSPECIFIED
http://people.bath.ac.uk/lc287/publications.htmlAuthor
DepartmentsFaculty of Science > Pharmacy & Pharmacology
Faculty of Science > Chemistry
Research CentresCentre for Regenerative Medicine
RefereedYes
StatusPublished
ID Code34794

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