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Transdifferentiation in developmental biology, disease, and in therapy


Reference:

Thowfeequ, S., Myatt, E.-J. and Tosh, D., 2007. Transdifferentiation in developmental biology, disease, and in therapy. Developmental Dynamics, 236 (12), pp. 3208-3217.

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Official URL:

http://dx.doi.org/10.1002/dvdy.21336

Abstract

Transdifferentiation (or metaplasia) refers to the conversion of one cell type to another. Because transdifferentiation normally occurs between cells that arise from the same region of the embryo, understanding the molecular and cellular events in cell type transformations may help to explain the mechanisms underlying normal development. Here we review examples of transdifferentiation in nature focusing on the possible role of cell type switching in metamorphosis and regeneration. We also examine transdifferentiation in mammals in relation to disease and the use of transdifferentiated cells in cellular therapy.

Details

Item Type Articles
CreatorsThowfeequ, S., Myatt, E.-J. and Tosh, D.
DOI10.1002/dvdy.21336
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3486

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