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The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide


Reference:

Kanakubo, A., Gray, D., Innocent, N., Wonnacott, S. and Gallagher, T., 2006. The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide. Bioorganic & Medicinal Chemistry Letters, 16 (17), pp. 4648-4651.

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Official URL:

http://dx.doi.org/10.1016/j.bmcl.2006.05.100

Abstract

The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [H-3]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. (c) 2006 Elsevier Ltd. All rights reserved.

Details

Item Type Articles
CreatorsKanakubo, A., Gray, D., Innocent, N., Wonnacott, S. and Gallagher, T.
DOI10.1016/j.bmcl.2006.05.100
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3670

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