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The thermal behaviour of enzyme activity: implications for biotechnology


Reference:

Eisenthal, R., Peterson, M. E., Daniel, R. M. and Danson, M. J., 2006. The thermal behaviour of enzyme activity: implications for biotechnology. Trends in Biotechnology, 24 (7), pp. 289-292.

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Official URL:

http://www.sciencedirect.com/science/article/pii/S0167779906001272

Abstract

The way that enzymes respond to temperature is fundamental to many areas of biotechnology. This has long been explained in terms of enzyme stability and catalytic activation energy, but recent observations of enzyme behaviour suggest that this picture is incomplete. We have developed and experimentally validated a new model to describe the effect of temperature on enzymes; this model incorporates additional fundamental parameters that enable a complete description of the effects of temperature on enzyme activity. In this article, we consider the biotechnological implications of this model in the areas of enzyme engineering, enzyme reactor operation and the selection and/or screening of useful enzymes from the environment.

Details

Item Type Articles
CreatorsEisenthal, R., Peterson, M. E., Daniel, R. M. and Danson, M. J.
DOI10.1016/j.tibtech.2006.05.004
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3699
Additional InformationID number: ISI:000239369100001

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